A simple, accurate, precise and sensitive UV spectrophotometric method was developed for the determination of fexofenadine HCl in bulk and suspension dosage form. The solvent used is methanol and the wavelength corresponding to maximum absorbance of the drug was found at 220 nm. Beer’s law was observed in the concentration range of 5 – 20 μg/ml with correlation coefficient 0.993. The linear regression equation obtained by least square regression method were y=0.051x + 0.002, where y is the absorbance and x is the concentration of the pure drug solution. The method was validated for several parameters like accuracy, precision as per ICH guidelines Q2 (R1). The values of relative standard deviation and % recovery were found to be satisfactory, indicating that the proposed method is precise and accurate and hence can be used for the routine analysis of fexofenadine hydrochloride in bulk and suspension dosage form.
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